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Single cell transcriptome analysis reveals human prostate cancer cells upregulate retinoic acid signalling in response to androgen withdrawal

Clark Ashlee K , Nim Hieu , Lister Natalie , Lawrence Mitchell G , Keerthikumar Shivakumar , Goode David L , MURAL , Wang Hong , Papargiris Melissa , Ryan Andrew , Azad Arun , Frydenberg Mark , Risbridger Gail P , Taylor Renea A

A current challenge in cancer therapeutics is incomplete response to treatment and emergence of therapy-resistant disease. Androgen deprivation therapy (ADT), the standard treatment for advanced prostate cancer, and effectively reduces the tumour burden in most patients. Yet, residual tumour cells that withstand ADT eventually develop lethal castration-resistance. Eliminating these castrate-tolerant cells, by combining ADT with other treatments, might delay or even prevent cas...

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oa0001p021 | (1) | PacRim7

Estrogen receptor alpha controls gene expression via translational offsetting

Lorent Julie , Rebello Richard J , van Hoef Vincent , Lawrence Mitchell G , Szkop Krzysztof J , Kusnadi Eric , Samreen Baila , Balanathan Preetika , Scharmann Karin , Takizawa Itsuhiro , Leidel Sebastian A , Risbridger Gail P , Topisirovic Ivan , Larsson Ola , Furic Luc

Estrogen receptor alpha (ERα) activity is associated with increased cancer cell proliferation. Studies aiming to understand the impact of ERα on cancer-associated phenotypes have largely been limited to its transcriptional activity. Herein, we demonstrate that ERα coordinates its transcriptional output with selective modulation of mRNA translation. Importantly, translational perturbations caused by depletion of ERα largely manifest as translational of...

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oa0001p042 | (1) | PacRim7