oa0001p003 | (1) | PacRim7
Bally Marcel B
, Abrams Michael
, Redelmier Tom R
, Gilabert-Oriol Roger
, Heroux Devon
, Chen Kent
, Leung Ada WY
We have recently discovered that metals which coordinate with selected compounds can be prepared inside liposomes. This technology, which we refer to as Metaplex technology, is enabling development of a brand new class of therapeutics. Previously the development of metal drug complexes (CDCs) has been hindered because of their very poor aqueous solubility. As an example, diethyldithiocarbamate (DDC) is the primary metabolite of disulfiram, an approved drug for the treatm...