Searchable abstracts of presentations at key conferences in oncology

Oncology Abstracts

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oa0001p042 | (1) | PacRim7

PARP inhibitor and CX-5461 combination therapy as a novel treatment strategy for castrate-resistant prostate cancer

Porter Laura H , Lawrence Mitchell G , Choo Nicholas K , Sandhu Shahneen , Wang Hong , Melbourne Urological Research Alliance (MURAL) , Pook David , Sanij Elaine , Pearson Richard B , Hannan Ross , Furic Luc , Taylor Renea A , Risbridger Gail P

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oa0001p031 | (1) | PacRim7

New combination therapies for castration-resistant prostate cancer

Lawrence Mitchell G , Porter Laura H , Obinata Daisuke , Sandhu Shahneen , Selth Luke A , Wong Stephen Q , Choo Nicholas , Pook David , Pezaro Carmel J , Goode David L , Clark Ashlee K , Papargiris Melissa , Toivanen Roxanne , Dehm Scott M , Melbourne Urological Research Alliance Scott M , CASCADE Scott M , kConfab Scott M , Thorne Heather , Tilley Wayne D , Pearson Richard B , Hannan Ross D , Murphy Declan G , Frydenberg Mark , Furic Luc , Taylor Renea A , Risbridger Gail P

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oa0001p013 | (1) | PacRim7

Single cell transcriptome analysis reveals human prostate cancer cells upregulate retinoic acid signalling in response to androgen withdrawal

Clark Ashlee K , Nim Hieu , Lister Natalie , Lawrence Mitchell G , Keerthikumar Shivakumar , Goode David L , MURAL , Wang Hong , Papargiris Melissa , Ryan Andrew , Azad Arun , Frydenberg Mark , Risbridger Gail P , Taylor Renea A

A current challenge in cancer therapeutics is incomplete response to treatment and emergence of therapy-resistant disease. Androgen deprivation therapy (ADT), the standard treatment for advanced prostate cancer, and effectively reduces the tumour burden in most patients. Yet, residual tumour cells that withstand ADT eventually develop lethal castration-resistance. Eliminating these castrate-tolerant cells, by combining ADT with other treatments, might delay or even prevent cas...
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oa0001p051 | (1) | PacRim7

Targeting HP1-alpha for prevention and treatment of neuroendocrine prostate cancer

Ci Xinpei , Lin Dong , Collins Colin , Lallous Nada , Hsing Michael , Cherkasov Art , Wang Yuzhuo

NEPC is a lethal subtype of PCa frequently arising from adenocarcinoma via NE transdifferentiation following ADT. In AACR-PCF West Dream Team series of sequential biopsies of over 300 CRPC biopsies, NEPC was discovered in 17% of cases, making neuroendocrine transdifferentiation one of the most common mechanisms underlying ADT resistance. However, a mechanistic understanding of both NEPC development and its aggressiveness remain elusive. Research in this field has been hampered...
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Published by BioScientifica

Oncology Abstracts
ISSN 2631-4657 (online)
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