PacRim7 7th PacRim Meeting Poster Presentations (1) (52 abstracts)
A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer progression
N Stylianou 1 , ML Lehman 1, , C Wang 1 , AT Fard 1 , A Rockstroh 1 , L Fazli 2 , L Jovanovic 1 , M Ward 3 , MC Sadowski 1 , AS Kashyap 4 , R Buttyan 2 , ME Gleave 2 , TF Westbrook 5 , ED Williams 1 , JH Gunter 1 , CC Nelson 1 & BG Hollier 1
1Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia; 2Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada; 3Glycation and Diabetic Complications Group, Mater Research Institute, Translational Research Institute, School of Medicine, University of Queensland, Brisbane, QLD, Australia; 4Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia; 5Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states via the epithelial-mesenchymal transition (EMT) program can regulate metastatic processes, cancer progression, and treatment resistance. Transcriptional investigations using reversible models of EMT, revealed the mesenchymal-to-epithelial reverting transition (MErT) to be enriched in clinical samples of metastatic castrate resistant prostate cancer (mCRPC). From this enrichment, a metastasis-derived gene signature was identified that predicted more rapid cancer relapse and reduced survival across multiple human carcinoma types. Additionally, the transcriptional profile of MErT is not a simple mirror image of EMT as tumour cells retain a transcriptional ‘memory’ following a reversible EMT. This memory was also enriched in mCRPC samples. Cumulatively, our studies reveal the transcriptional profile of epithelial-mesenchymal plasticity and highlight the unique transcriptional properties of MErT. Furthermore, our findings provide evidence to support the association of epithelial plasticity with poor clinical outcomes in multiple human carcinoma types.
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Oncology Abstracts
ISSN 2631-4657 (online)
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